The 12 Best HIPAA Compliance Software in 2026
Ranked by real buyer interest on ISMS Directory over the last 30 days. Updated November 2026.
1. Comp AI
US open-source-friendly compliance automation platform for SOC 2, ISO 27001, and HIPAA evidence.
- HIPAA
- SOC 2
- ISO 27001
- GDPR
- Multi-framework
- ISO 42001
2. Zerberus.ai
Zerberus.ai helps SaaS companies fast-track ISO 27001 & SOC 2 compliance in just 10 days using AI-driven automation, one-click remediation, and real-time risk mapping tailored to your tech stack.
- HIPAA
- ISO 27001
- ISO 42001
- SOC 2 Type 2
- GDPR
- Multi-framework
3. LowerPlane
LowerPlane is a compliance automation platform that helps growing companies achieve SOC 2, ISO 27001, GDPR, and HIPAA faster — with continuous monitoring, policy automation, and custom review workflows.
- HIPAA
- ISO 27001
- SOC 2 Type 2
- GDPR
- Multi-framework
- PCI DSS
4. MetricStream
Enterprise GRC suite for operational risk, compliance, audit, and third-party risk at large institutions.
- HIPAA
- SOX
- ISO 27001
- NIST CSF
- Multi-framework
- CCPA
5. Strike Graph
AI-native compliance management platform that accelerates audits and eliminates redundant work across 5,000+ data source integrations.
- HIPAA
- ISO 27001
- ISO 27701
- ISO 42001
- SOC 2
- GDPR
6. heygrc
GitHub App that reviews every pull request against your compliance frameworks, flags changes that put a control at risk, and says exactly what to fix.
- HIPAA
- ISO 27001
- SOC 2
- GDPR
- EU AI ACT
- DORA
7. Anecdotes
Enterprise agentic GRC platform with 230+ integrations and 40+ pre-mapped frameworks for Fortune 500 compliance programs.
- HIPAA
- ISO 27001
- ISO 27701
- ISO 42001
- ISO 22301
- SOC 2
8. Scytale
AI-powered compliance automation platform with dedicated human experts, supporting 60+ security and privacy frameworks.
- HIPAA
- ISO 27001
- ISO 27701
- ISO 42001
- ISO 9001
- ISO 22301
9. Vanta
AI-powered trust management platform that automates compliance, manages risk, and builds customer trust across 35+ frameworks.
- HIPAA
- ISO 27001
- SOC 2
- GDPR
- HITRUST
- ISO 42001
10. Hyperproof
Intelligent GRC platform that transforms compliance from a cost center into a competitive advantage with AI-powered automation.
- HIPAA
- ISO 27001
- SOC 2
- GDPR
- PCI DSS
- NIST CSF
11. Scrut Automation
Scrut Automation simplifies continuous compliance automation for cloud-native companies.
- HIPAA
- ISO 27001
- SOC 2
- GDPR
- PCI DSS
- ISO 27701
12. AuditBoard
Enterprise connected risk platform trusted by over 50% of the Fortune 500 for audit, risk, and compliance management.
- HIPAA
- ISO 27001
- SOC 2
- GDPR
- SOX
- NIST CSF
Compare at a glance
| Rank | Provider | Listed frameworks | Listed regions | Profile |
|---|---|---|---|---|
| 1 | Comp AI | HIPAA, SOC 2, ISO 27001, GDPR, Multi-framework, ISO 42001 | United States, Global | View profile |
| 2 | Zerberus.ai | HIPAA, ISO 27001, ISO 42001, SOC 2 Type 2, GDPR, Multi-framework | Asia, Europe, India +3 more | View profile |
| 3 | LowerPlane | HIPAA, ISO 27001, SOC 2 Type 2, GDPR, Multi-framework, PCI DSS | Asia, Europe, Middle East +2 more | View profile |
| 4 | MetricStream | HIPAA, SOX, ISO 27001, NIST CSF, Multi-framework, CCPA | United States, Global, Asia | View profile |
| 5 | Strike Graph | HIPAA, ISO 27001, ISO 27701, ISO 42001, SOC 2, GDPR | Global | View profile |
| 6 | heygrc | HIPAA, ISO 27001, SOC 2, GDPR, EU AI ACT, DORA | Global | View profile |
| 7 | Anecdotes | HIPAA, ISO 27001, ISO 27701, ISO 42001, ISO 22301, SOC 2 | Global | View profile |
| 8 | Scytale | HIPAA, ISO 27001, ISO 27701, ISO 42001, ISO 9001, ISO 22301 | Global | View profile |
| 9 | Vanta | HIPAA, ISO 27001, SOC 2, GDPR, HITRUST, ISO 42001 | Global | View profile |
| 10 | Hyperproof | HIPAA, ISO 27001, SOC 2, GDPR, PCI DSS, NIST CSF | Global | View profile |
| 11 | Scrut Automation | HIPAA, ISO 27001, SOC 2, GDPR, PCI DSS, ISO 27701 | Global | View profile |
| 12 | AuditBoard | HIPAA, ISO 27001, SOC 2, GDPR, SOX, NIST CSF | Global | View profile |
Frequently asked questions
- How is this HIPAA Compliance Software ranking determined?
- Providers are first filtered to those that substantively cover HIPAA Compliance Software in the ISMS Directory catalogue, then ordered by real buyer interest — the directory traffic and engagement each provider received over the last 30 days. It is not paid placement and it is not an editorial opinion.
- How often is the list updated?
- The ranking recomputes from live directory-demand data on a rolling 30-day window and refreshes roughly every 15 minutes, so it reflects current interest rather than a one-off 2026 snapshot.
- Why are only 12 providers shown?
- This list shows the top providers by demand for HIPAA Compliance Software. Pages with fewer than three substantively-matching providers are not published at all, so every entry here represents a real, comparable option.
- How can my company appear here?
- Get listed in ISMS Directory with HIPAA Compliance Software expertise. Ranking is earned through genuine directory demand — there is no way to pay for a position.